Genetic diversity of Nipah virus in Bangladesh

BackgroundNipah virus (NiV) infection, often fatal in humans, is primarily transmitted Bangladesh through the consumption of date palm sap contaminated by Pteropus bats. Person-to-person transmission also common and increases concern large outbreaks. This study aimed to characterize molecular epidemiology, phylogenetic relationship, evolution nucleocapsid gene (N gene) NiV.MethodsWe conducted detection, genetic characterization, Bayesian time-scale analyses NiV using pooled Pteropid bat roost urine samples from an outbreak area 2012 archived RNA case patients identified during 2012–2018 Bangladesh.ResultsNiV-RNA was detected 19% (38/456) among them; nine N sequences were recovered. We retrieved 53% (21 out 39) patients. Phylogenetic analysis revealed that all Bangladeshi strains belonged NiV-BD genotype had evolutionary rate 4.64 × 10?4 substitutions/site/year. The suggested diverged 1995 formed two sublineages.ConclusionThis provides further evidence Malaysian genotypes recently continue evolve. More extensive surveillance bats human will be helpful explore strain diversity virulence potential infect humans direct or person-to-person transmission.